Obesity and loosing weight

Mike eats all day and still is lean and thin while John is on perpetual dieting but remains obese. So what causes overweight?
Here is an incomplete list:
-Imbalance between caloric intake and energy expenditure
Hormonal causes
–Associated with poor linear growth
–Hypercortisolism: Cushing syndrome is any type of glucocorticoid excess (endogenous or exogenous); Cushing disease describes pituitary ACTH overproduction
–Hypothyroidism
–Growth hormone deficiency
Insulinoma
Hypothalamic obesity
–Tumors (e.g., craniopharyngiomas)
–Following neurosurgery or irradiation
–Head trauma
–Infiltrative/inflammatory
Genetic syndromes
Drugs
–Chronic glucocorticoids
–Neuropsychotropic medications
Adiposogenital dystrophy syndrome

Overweight persons generally try many options: from herbal things to sitting on vibrator machines.Anything which does not follow the following principle will be useless:
THE AMOUNT OF WEIGHT GAIN (OR LOSS)IS EQUIVALENT TO DIFFERENCE BETWEEN CALORIES INTAKE AND CALORIES SPENT

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